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Volume 39, Issue 5; May 1, 2008
Editorials
Original Contributions
Research Letters
Special Reports
Topical Review
Letters to the Editor
Emerging Therapies
AHA/ASA Science Advisory
Corrections
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Editorials
Leukoaraiosis: From an Ancient Term to an Actual Marker of Poor Prognosis
Leonardo Pantoni
Stroke. 2008;39:1401-1403; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.505602
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Ultrasound-Enhanced Thrombolysis: From Bedside to Bench
Georgios Tsivgoulis and Andrei Alexandrov
Stroke. 2008;39:1404-1405; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.505594
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The Balance Between Stroke Prevention and Bleeding Risk in Atrial Fibrillation: A Delicate Balance Revisited
Gregory Y.H. Lip
Stroke. 2008;39:1406-1408; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.506832
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Original Contributions
Severity of Leukoaraiosis and Susceptibility to Infarct Growth in Acute Stroke
Hakan Ay, E. Murat Arsava, Jonathan Rosand, Karen L. Furie, Aneesh B. Singhal, Pamela W. Schaefer, Ona Wu, R. Gilberto Gonzalez, Walter J. Koroshetz, and A. Gregory Sorensen
Stroke. 2008;39:1409-1413; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.501932
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Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period: The Leukoaraiosis and Disability Study
Alida A. Gouw, Wiesje M. van der Flier, Franz Fazekas, Elisabeth C.W. van Straaten, Leonardo Pantoni, Anna Poggesi, Domenico Inzitari, Timo Erkinjuntti, Lars O. Wahlund, Gunhild Waldemar, Reinhold Schmidt, Philip Scheltens, Frederik Barkhof on behalf of the LADIS Study Group
Stroke. 2008;39:1414-1420; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.498535
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Unrecognized Myocardial Infarction in Relation to Risk of Dementia and Cerebral Small Vessel Disease
M. Arfan Ikram, Marieke van Oijen, Frank Jan de Jong, Jan A. Kors, Peter J. Koudstaal, Albert Hofman, Jacqueline C.M. Witteman, and Monique M.B. Breteler
Stroke. 2008;39:1421-1426; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.501106
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Cerebral Ischemic Lesions on Diffusion-Weighted Imaging Are Associated With Neurocognitive Decline After Cardiac Surgery
P. Alan Barber, Sylvia Hach, Lynette J. Tippett, Linda Ross, Alan F. Merry, and Paget Milsom
Stroke. 2008;39:1427-1433; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502989
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Genome Screen to Detect Linkage to Intracranial Aneurysm Susceptibility Genes: The Familial Intracranial Aneurysm (FIA) Study
Tatiana Foroud, Laura Sauerbeck, Robert Brown, Craig Anderson, Daniel Woo, Dawn Kleindorfer, Matthew L. Flaherty, Ranjan Deka, Richard Hornung, Irene Meissner, Joan E. Bailey-Wilson, Guy Rouleau, E. Sander Connolly, Dongbing Lai, Daniel L. Koller, John Huston, III, Joseph P. Broderick, and the FIA Study Investigators
Stroke. 2008;39:1434-1440; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502930
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Circulating Endothelial Progenitor Cells as a New Marker of Endothelial Dysfunction or Repair in Acute Stroke
Supplemental Methods
Kon Chu, Keun-Hwa Jung, Soon-Tae Lee, Hee-Kwon Park, Dong-In Sinn, Jeong-Min Kim, Dong-Hyun Kim, Jin-Hee Kim, Se-Jeong Kim, Eun-Cheol Song, Manho Kim, Sang Kun Lee, and Jae-Kyu Roh
Stroke. 2008;39:1441-1447; published online before print March 20 2008, doi:10.1161/STROKEAHA.107.499236
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Enhanced Expression of Lp-PLA
2
and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques
Dallit Mannheim, Joerg Herrmann, Daniele Versari, Mario Gössl, Fredric B. Meyer, Joseph P. McConnell, Lilach O. Lerman, and Amir Lerman
Stroke. 2008;39:1448-1455; published online before print March 20 2008, doi:10.1161/STROKEAHA.107.503193
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Progression of Symptomatic Intracranial Large Artery Atherosclerosis Is Associated With a Proinflammatory State and Impaired Fibrinolysis
Juan F. Arenillas, José Álvarez-Sabín, Carlos A. Molina, Pilar Chacón, Israel Fernández-Cadenas, Marc Ribó, Pilar Delgado, Marta Rubiera, Anna Penalba, Alex Rovira, and Joan Montaner
Stroke. 2008;39:1456-1463; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.498600
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A Pilot Randomized Clinical Safety Study of Sonothrombolysis Augmentation With Ultrasound-Activated Perflutren-Lipid Microspheres for Acute Ischemic Stroke
Andrei V. Alexandrov, Robert Mikulik, Marc Ribo, Vijay K. Sharma, Annabelle Y. Lao, Georgios Tsivgoulis, Rebecca M. Sugg, Andrew Barreto, Paul Sierzenski, Marc D. Malkoff, and James C. Grotta
Stroke. 2008;39:1464-1469; published online before print March 20 2008, doi:10.1161/STROKEAHA.107.505727
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Sonothrombolysis With Transcranial Color-Coded Sonography and Recombinant Tissue-Type Plasminogen Activator in Acute Middle Cerebral Artery Main Stem Occlusion: Results From a Randomized Study
Jürgen Eggers, Inke R. König, Björn Koch, Götz Händler, and Günter Seidel
Stroke. 2008;39:1470-1475; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.503870
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Quantification of Microspheres Appearance in Brain Vessels: Implications for Residual Flow Velocity Measurements, Dose Calculations, and Potential Drug Delivery
Vijay K. Sharma, Georgios Tsivgoulis, Annabelle Y. Lao, Marc D. Malkoff, Anne W. Alexandrov, and Andrei V. Alexandrov
Stroke. 2008;39:1476-1481; published online before print March 20 2008, doi:10.1161/STROKEAHA.107.501593
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Risks and Benefits of Oral Anticoagulation Compared With Clopidogrel Plus Aspirin in Patients With Atrial Fibrillation According to Stroke Risk: The Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE-W)
Jeff S. Healey, Robert G. Hart, Janice Pogue, Marc A. Pfeffer, Stefan H. Hohnloser, Raffaele De Caterina, Greg Flaker, Salim Yusuf, and Stuart J. Connolly
Stroke. 2008;39:1482-1486; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.500199
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Endovascular Thrombectomy and Thrombolysis for Severe Cerebral Sinus Thrombosis: A Prospective Study
Jan Stam, Charles B.L.M. Majoie, Otto M. van Delden, Krijn P. van Lienden, and Jim A. Reekers
Stroke. 2008;39:1487-1490; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.502658
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Intra-arterial Thrombolysis of Acute Iatrogenic Intracranial Arterial Occlusion Attributable to Neuroendovascular Procedures or Coronary Angiography
Marcel Arnold, Urs Fischer, Gerhard Schroth, Krassen Nedeltchev, Joerg Isenegger, Luca Remonda, Stephan Windecker, Caspar Brekenfeld, and Heinrich P. Mattle
Stroke. 2008;39:1491-1495; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.506279
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Staged Escalation Therapy in Acute Basilar Artery Occlusion: Intravenous Thrombolysis and On-Demand Consecutive Endovascular Mechanical Thrombectomy: Preliminary Experience in 16 Patients
Thomas Pfefferkorn, Thomas E. Mayer, Christian Opherk, Nils Peters, Andreas Straube, Hans-Walter Pfister, Markus Holtmannspötter, Stefanie Müller-Schunk, Martin Wiesmann, and Martin Dichgans
Stroke. 2008;39:1496-1500; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.505123
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Predictors and Outcomes of Intraprocedural Rupture in Patients Treated for Ruptured Intracranial Aneurysms: The CARAT Study
Lucas Elijovich, Randall T. Higashida, Michael T. Lawton, Gary Duckwiler, Steven Giannotta, S. Claiborne Johnston for The Cerebral Aneurysm Rerupture After Treatment (CARAT) Investigators
Stroke. 2008;39:1501-1506; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.504670
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Functional MRI Correlates of Lower Limb Function in Stroke Victims With Gait Impairment
Christian Enzinger, Heidi Johansen-Berg, Helen Dawes, Marko Bogdanovic, Jonathan Collett, Claire Guy, Stefan Ropele, Udo Kischka, Derick Wade, Franz Fazekas, and Paul M. Matthews
Stroke. 2008;39:1507-1513; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.501999
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Racial and Ethnic Differences in Postacute Rehabilitation Outcomes After Stroke in the United States
Kenneth J. Ottenbacher, Joanna Campbell, Yong-Fang Kuo, Anne Deutsch, Glenn V. Ostir, and Carl V. Granger
Stroke. 2008;39:1514-1519; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.501254
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Remodeling the Brain: Plastic Structural Brain Changes Produced by Different Motor Therapies After Stroke
Supplemental Material
Lynne V. Gauthier, Edward Taub, Christi Perkins, Magdalene Ortmann, Victor W. Mark, and Gitendra Uswatte
Stroke. 2008;39:1520-1525; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502229
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The Influence of Psychiatric Morbidity on Return to Paid Work After Stroke in Younger Adults: The Auckland Regional Community Stroke (ARCOS) Study, 2002 to 2003
Nick Glozier, Maree L. Hackett, Varsha Parag, Craig S. Anderson for the Auckland Regional Community Stroke (ARCOS) Study Group
Stroke. 2008;39:1526-1532; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.503219
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Stroke Disparities in Older Americans: Is Wealth a More Powerful Indicator of Risk Than Income and Education?
Mauricio Avendano and M. Maria Glymour
Stroke. 2008;39:1533-1540; published online before print April 24 2008, doi:10.1161/STROKEAHA.107.490383
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MRI Detection of Secondary Damage After Stroke: Chronic Iron Accumulation in the Thalamus of the Rat Brain
Carles Justicia, Pedro Ramos-Cabrer, and Mathias Hoehn
Stroke. 2008;39:1541-1547; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.503565
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Mild Induced Hypertension Improves Blood Flow and Oxygen Metabolism in Transient Focal Cerebral Ischemia
Hwa Kyoung Shin, Masaki Nishimura, Phillip B. Jones, Hakan Ay, David A. Boas, Michael A. Moskowitz, and Cenk Ayata
Stroke. 2008;39:1548-1555; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.499483
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Albumin Therapy Augments the Effect of Thrombolysis on Local Vascular Dynamics in a Rat Model of Arteriolar Thrombosis: A Two-Photon Laser-Scanning Microscopy Study
Hee-Pyoung Park, Anitha Nimmagadda, Richard A. DeFazio, Raul Busto, Ricardo Prado, and Myron D. Ginsberg
Stroke. 2008;39:1556-1562; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502195
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Angiogenesis Detected After Embolic Stroke in Rat Brain Using Magnetic Resonance T2*WI
Guangliang Ding, Quan Jiang, Lian Li, Li Zhang, Zheng Gang Zhang, Karyn A. Ledbetter, Lakshman Gollapalli, Swayamprava Panda, Qingjiang Li, James R. Ewing, and Michael Chopp
Stroke. 2008;39:1563-1568; published online before print March 20 2008, doi:10.1161/STROKEAHA.107.502146
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Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia
Piotr Walczak, Jian Zhang, Assaf A. Gilad, Dorota A. Kedziorek, Jesus Ruiz-Cabello, Randell G. Young, Mark F. Pittenger, Peter C.M. van Zijl, Judy Huang, and Jeff W.M. Bulte
Stroke. 2008;39:1569-1574; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502047
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Induction of Immunologic Tolerance to Myelin Basic Protein Prevents Central Nervous System Autoimmunity and Improves Outcome After Stroke
J. Michael Gee, Angela Kalil, Matthew Thullbery, and Kyra J. Becker
Stroke. 2008;39:1575-1582; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.501486
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Research Letters
Stroke Health and Risk Education (SHARE) Pilot Project: Feasibility and Need for Church-Based Stroke Health Promotion in a Bi-Ethnic Community
Darin B. Zahuranec, Lewis B. Morgenstern, Nelda M. Garcia, Kathleen M. Conley, Lynda D. Lisabeth, Grace S. Rank, Melinda A. Smith, William J. Meurer, Ken Resnicow, and Devin L. Brown
Stroke. 2008;39:1583-1585; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.503557
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Whole Genome Analyses Suggest Ischemic Stroke and Heart Disease Share an Association With Polymorphisms on Chromosome 9p21
Mar Matarin, W. Mark Brown, Andrew Singleton, John A. Hardy, James F. Meschia for the ISGS investigators
Stroke. 2008;39:1586-1589; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.502963
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Genetic Variation of the Androgen Receptor and Risk of Myocardial Infarction and Ischemic Stroke in Women
Kathryn M. Rexrode, Paul M. Ridker, Hillary H. Hegener, Julie E. Buring, JoAnn E. Manson, and Robert Y.L. Zee
Stroke. 2008;39:1590-1592; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.508218
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Genetic Variation in Soluble Epoxide Hydrolase (
EPHX2
) Is Associated With an Increased Risk of Ischemic Stroke in White Europeans
Andreas Gschwendtner, Stephan Ripke, Tobias Freilinger, Peter Lichtner, Bertram Müller-Myhsok, H.-Erich Wichmann, Thomas Meitinger, and Martin Dichgans
Stroke. 2008;39:1593-1596; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.502179
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Morphological But Not Functional Changes of the Carotid Artery Are Associated With the Extent of Coronary Artery Disease in Patients With Preserved Left Ventricular Function
Kenichi Sugioka, Takeshi Hozumi, Shinichi Iwata, Hiroki Oe, Takuhiro Okuyama, Nobuyuki Shirai, Hajime Yamashita, Shoichi Ehara, Toru Kataoka, Junichi Yoshikawa, Makiko Ueda, and Minoru Yoshiyama
Stroke. 2008;39:1597-1599; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.502732
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Diabetes Increases Atrophy and Vascular Lesions on Brain MRI in Patients With Symptomatic Arterial Disease
Audrey M. Tiehuis, Yolanda van der Graaf, Frank L. Visseren, Koen L. Vincken, Geert Jan Biessels, Auke P.A. Appelman, L. Jaap Kappelle, Willem P.T.M. Mali for the SMART Study Group
Stroke. 2008;39:1600-1603; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.506089
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Observation of the Lenticulostriate Arteries in the Human Brain In Vivo Using 7.0T MR Angiography
Zang-Hee Cho, Chang-Ki Kang, Jae-Yong Han, Sang-Hoon Kim, Kyoung-Nam Kim, Suk-Min Hong, Cheol-Wan Park, and Young-Bo Kim
Stroke. 2008;39:1604-1606; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.508002
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Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions
Hirokazu Bokura, Shuhei Yamaguchi, Kenichi Iijima, Atsushi Nagai, and Hiroaki Oguro
Stroke. 2008;39:1607-1609; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.508630
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Cerebrospinal Fluid Tenascin-C Increases Preceding the Development of Chronic Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage
Hidenori Suzuki, Noriaki Kinoshita, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, and Waro Taki
Stroke. 2008;39:1610-1612; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.505735
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Middle Cerebral Artery Occlusion in the Rabbit Using Selective Angiography: Application for Assessment of Thrombolysis
Reza Jahan, Daphne Stewart, Harry V. Vinters, William Yong, Fernando Vinuela, Pete Vandeberg, and Victor J. Marder
Stroke. 2008;39:1613-1615; published online before print March 13 2008, doi:10.1161/STROKEAHA.107.507376
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Clinical and Tissue Response to Intravenous Thrombolysis in Tandem Internal Carotid Artery/Middle Cerebral Artery Occlusion: An MRI Study
Götz Thomalla, Anna Kruetzelmann, Susanne Siemonsen, Christian Gerloff, Michael Rosenkranz, Joachim Röther, and Jens Fiehler
Stroke. 2008;39:1616-1618; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.504951
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Benchmarks and Determinants of Adherence to Stroke Performance Measures
Judith A. Hinchey, Timothy Shephard, Sarah T. Tonn, Robin Ruthazer, Harry P. Selker, and David M. Kent
Stroke. 2008;39:1619-1620; published online before print March 6 2008, doi:10.1161/STROKEAHA.107.496570
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Special Reports
Acute Stroke Imaging Research Roadmap
Max Wintermark, Gregory W. Albers, Andrei V. Alexandrov, Jeffry R. Alger, Roland Bammer, Jean-Claude Baron, Stephen Davis, Bart M. Demaerschalk, Colin P. Derdeyn, Geoffrey A. Donnan, James D. Eastwood, Jochen B. Fiebach, Marc Fisher, Karen L. Furie, Gregory V. Goldmakher, Werner Hacke, Chelsea S. Kidwell, Stephan P. Kloska, Martin Köhrmann, Walter Koroshetz, Ting-Yim Lee, Kennedy R. Lees, Michael H. Lev, David S. Liebeskind, Leif Ostergaard, William J. Powers, James Provenzale, Peter Schellinger, Robert Silbergleit, Alma Gregory Sorensen, Joanna Wardlaw, Ona Wu, and Steven Warach
Stroke. 2008;39:1621-1628; published online before print April 10 2008, doi:10.1161/STROKEAHA.107.512319
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Topical Review
Applications of Nitroimidazole In Vivo Hypoxia Imaging in Ischemic Stroke
Masashi Takasawa, Ramez Reda Moustafa, and Jean-Claude Baron
Stroke. 2008;39:1629-1637; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.485938
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Letters to the Editor
Detecting Paroxysmal Atrial Fibrillation After Ischemic Stroke and Transient Ischemic Attack: If You Dont Look, You Wont Find
David J. Gladstone, John Blakely, Paul Dorian, Melanie Spring, Jiming Fang, Frank L. Silver, Moira K. Kapral for the EMBRACE Pilot Study Group
Stroke. 2008;39:e78-e79; published online before print April 3 2008, doi:10.1161/STROKEAHA.107.513002
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Response to Letter by Gladstone et al
Etienne Delacrétaz
Stroke. 2008;39:e80; published online before print April 3 2008, doi:10.1161/STROKEAHA.108.514380
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A Systematic Review of Immediate Anticoagulation for Ischemic Stroke of Presumed Cardioembolic Origin
Leonor C. Guedes and José M. Ferro
Stroke. 2008;39:e81-e82; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.513200
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Response to Letter by Guedes and Ferro
Maurizio Paciaroni, Giancarlo Agnelli, Sara Micheli, and Valeria Caso
Stroke. 2008;39:e83; published online before print March 27 2008, doi:10.1161/STROKEAHA.108.515668
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Correlation Between Carotid Intraplaque Hemorrhage and Clinical Symptoms
Luciano Cabral Albuquerque and Luis Eduardo Rohde
Stroke. 2008;39:e84; published online before print April 3 2008, doi:10.1161/STROKEAHA.108.513309
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Is the Use of Hypertonic Mannitol Appropriate in the Management of Intracerebral Hemorrhage?
E.S. Prakash
Stroke. 2008;39:e85; published online before print March 20 2008, doi:10.1161/STROKEAHA.108.516435
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Response to Letter by Prakash
Dániel Bereczki, Ming Liu, Gilmar Fernandes do Prado, and István Fekete
Stroke. 2008;39:e86-e87; published online before print March 20 2008, doi:10.1161/STROKEAHA.108.516914
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Uric Acid: Neuroprotective or Neurotoxic?
Peter H. Proctor
Stroke. 2008;39:e88; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.513242
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Response to Letter by Proctor
Jesse Dawson, Terence J. Quinn, and Matthew R. Walters
Stroke. 2008;39:e89; published online before print March 27 2008, doi:10.1161/STROKEAHA.108.515635
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Emerging Therapies
Antiplatelet Therapy for Secondary Prevention of Noncardioembolic Ischemic Stroke: A Critical Review
Martin J. ODonnell, Graeme J. Hankey, and John W. Eikelboom
Stroke. 2008;39:1638-1646; published online before print March 27 2008, doi:10.1161/STROKEAHA.107.497271
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CME
AHA/ASA Science Advisory
Update to the AHA/ASA Recommendations for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
Robert J. Adams, Greg Albers, Mark J. Alberts, Oscar Benavente, Karen Furie, Larry B. Goldstein, Philip Gorelick, Jonathan Halperin, Robert Harbaugh, S. Claiborne Johnston, Irene Katzan, Margaret Kelly-Hayes, Edgar J. Kenton, Michael Marks, Ralph L. Sacco, and Lee H. Schwamm
Stroke. 2008;39:1647-1652; published online before print March 5 2008, doi:10.1161/STROKEAHA.107.189063
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Corrections
Correction
Stroke. 2008;39:e90, doi:10.1161/STROKEAHA.106.000001
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