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About This Cover
Volume 40, Issue 11; November 1, 2009
Editorials
Original Contributions
Research Letters
Comments, Opinions, and Reviews
Topical Review
Cochrane Corner
AHA Scientific Statement
Letters to the Editor
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Table of Contents (PDF)
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Editorials
Should Modeling Methodology Suppress Anatomic Excellence?
Allan J. Fox, Sean P. Symons, Richard I. Aviv, Peter Howard, Robert Yeung, and Eric S. Bartlett
Stroke. 2009;40:3411-3412; published online before print September 3 2009, doi:10.1161/STROKEAHA.109.558452
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Statins Prevent Stroke Recurrences... But Can They Improve Stroke Outcome?
Alejandro A. Rabinstein
Stroke. 2009;40:3413-3414; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.561704
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Original Contributions
Electrical Stimulation of the Cerebral Cortex Exerts Antiapoptotic, Angiogenic, and Anti-Inflammatory Effects in Ischemic Stroke Rats Through Phosphoinositide 3-Kinase/Akt Signaling Pathway
Tanefumi Baba, Masahiro Kameda, Takao Yasuhara, Takamasa Morimoto, Akihiko Kondo, Tetsuro Shingo, Naoki Tajiri, Feifei Wang, Yasuyuki Miyoshi, Cesario V. Borlongan, Mitsunori Matsumae, and Isao Date
Stroke. 2009;40:e598-e605; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563627
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Induced Spreading Depression Evokes Cell Division of Astrocytes in the Subpial Zone, Generating Neural Precursor-Like Cells and New Immature Neurons in the Adult Cerebral Cortex
Jing-Hui Xue, Hiroji Yanamoto, Yukako Nakajo, Norimitsu Tohnai, Yoshikazu Nakano, Takuya Hori, Koji Iihara, and Susumu Miyamoto
Stroke. 2009;40:e606-e613; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.560334
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Imaging Data Reveal a Higher Pediatric Stroke Incidence Than Prior US Estimates
Nidhi Agrawal, S. Claiborne Johnston, Yvonne W. Wu, Stephen Sidney, and Heather J. Fullerton
Stroke. 2009;40:3415-3421; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.564633
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Low Serum Bilirubin Level as an Independent Predictor of Stroke Incidence: A Prospective Study in Korean Men and Women
Heejin Kimm, Ji Eun Yun, Jaeseong Jo, and Sun Ha Jee
Stroke. 2009;40:3422-3427; published online before print August 27 2009, doi:10.1161/STROKEAHA.109.560649
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Body Mass Index and Stroke Mortality by Smoking and Age at Menopause Among Korean Postmenopausal Women
Sang-Wook Yi, Nemekhee Odongua, Chung Mo Nam, Jae Woong Sull, and Heechoul Ohrr
Stroke. 2009;40:3428-3435; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.555144
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Candidate Gene Polymorphisms for Ischemic Stroke
Mar Matarin, W. Mark Brown, Hernandez Dena, Angela Britton, Fabienne Wavrant De Vrieze, Thomas G. Brott, Robert D. Brown, Jr, Bradford B. Worrall, L. Douglas Case, Stephen J. Chanock, E. Jeffrey Metter, Luigi Ferruci, Dale Gamble, John A. Hardy, Stephen S. Rich, Andrew Singleton, and James F. Meschia
Stroke. 2009;40:3436-3442; published online before print September 3 2009, doi:10.1161/STROKEAHA.109.558015
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Increased Risk of Stroke After a Herpes Zoster Attack: A Population-Based Follow-Up Study
Jiunn-Horng Kang, Jau-Der Ho, Yi-Hua Chen, and Herng-Ching Lin
Stroke. 2009;40:3443-3448; published online before print October 8 2009, doi:10.1161/STROKEAHA.109.562017
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Diagnostic Usefulness of the ABCD
2
Score to Distinguish Transient Ischemic Attack and Minor Ischemic Stroke From Noncerebrovascular Events: The North Dublin TIA Study
Orla C. Sheehan, Aine Merwick, Lisa A. Kelly, Niamh Hannon, Michael Marnane, Lorraine Kyne, Patricia M.E. McCormack, Joseph Duggan, Alan Moore, Joan Moroney, Leslie Daly, Dawn Harris, Gillian Horgan, and Peter J. Kelly
Stroke. 2009;40:3449-3454; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.557074
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Patients With Alzheimer Disease With Multiple Microbleeds: Relation With Cerebrospinal Fluid Biomarkers and Cognition
Jeroen D.C. Goos, M.I. Kester, Frederik Barkhof, Martin Klein, Marinus A. Blankenstein, Philip Scheltens, and Wiesje M. van der Flier
Stroke. 2009;40:3455-3460; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.558197
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Cerebral Microbleeds Are Frequent in Infective Endocarditis: A Case-Control Study
Isabelle Klein, Bernard Iung, Julien Labreuche, Agathe Hess, Michel Wolff, David Messika-Zeitoun, Philippa Lavallée, Jean-Pierre Laissy, Catherine Leport, Xavier Duval, and the IMAGE Study Group
Stroke. 2009;40:3461-3465; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.562546
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Inflammatory Biomarkers of Vascular Risk as Correlates of Leukoariosis
Clinton B. Wright, Yeseon Moon, Myunghee C. Paik, Truman R. Brown, LeRoy Rabbani, Mitsuhiro Yoshita, Charles DeCarli, Ralph Sacco, and Mitchell S.V. Elkind
Stroke. 2009;40:3466-3471; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.559567
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Association of Asymptomatic Peripheral Arterial Disease With Vascular Events in Patients With Stroke or Transient Ischemic Attack
Souvik Sen, Donald R. Lynch, Jr, Effie Kaltsas, Jennifer Simmons, Walter A. Tan, Jongyeol Kim, James Beck, and Wayne Rosamond
Stroke. 2009;40:3472-3477; published online before print August 27 2009, doi:10.1161/STROKEAHA.109.559278
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Elevated Cardiac Troponin I and Relationship to Persistence of Electrocardiographic and Echocardiographic Abnormalities After Aneurysmal Subarachnoid Hemorrhage
Marilyn Hravnak, J. Michael Frangiskakis, Elizabeth A. Crago, Yuefang Chang, Masaki Tanabe, John Gorcsan, III, and Michael B. Horowitz
Stroke. 2009;40:3478-3484; published online before print August 27 2009, doi:10.1161/STROKEAHA.109.556753
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Effects of Moderate-Dose Omega-3 Fish Oil on Cardiovascular Risk Factors and Mood After Ischemic Stroke: A Randomized, Controlled Trial
Sally D. Poppitt, Colin A. Howe, Fiona E. Lithander, Karen M. Silvers, Ruey-Bin Lin, John Croft, Yogini Ratnasabapathy, Robert A. Gibson, and Craig S. Anderson
Stroke. 2009;40:3485-3492; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.555136
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Diagnosing Delayed Cerebral Ischemia With Different CT Modalities in Patients With Subarachnoid Hemorrhage With Clinical Deterioration
Jan Willem Dankbaar, Nicolien K. de Rooij, Birgitta K. Velthuis, Catharina J.M. Frijns, Gabriel J.E. Rinkel, and Irene C. van der Schaaf
Stroke. 2009;40:3493-3498; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.559013
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Noninvasive Detection of Vertebral Artery Stenosis: A Comparison of Contrast-Enhanced MR Angiography, CT Angiography, and Ultrasound
Sofia Khan, Philip Rich, Andrew Clifton, and Hugh S. Markus
Stroke. 2009;40:3499-3503; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.556035
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HINTS to Diagnose Stroke in the Acute Vestibular Syndrome: Three-Step Bedside Oculomotor Examination More Sensitive Than Early MRI Diffusion-Weighted Imaging
Jorge C. Kattah, Arun V. Talkad, David Z. Wang, Yu-Hsiang Hsieh, and David E. Newman-Toker
Stroke. 2009;40:3504-3510; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.551234
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Data Supplement
Carotid Artery Imaging for Secondary Stroke Prevention: Both Imaging Modality and Rapid Access to Imaging Are Important
Joanna M. Wardlaw, Matt D. Stevenson, Francesca Chappell, Peter M. Rothwell, Jonathan Gillard, Gavin Young, Steven M. Thomas, Giles Roditi, and Michael J. Gough
Stroke. 2009;40:3511-3517; published online before print September 3 2009, doi:10.1161/STROKEAHA.109.557017
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A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke: Modified Randomized Exposure Controlled Trial (mRECT)
Philip Teal, Stephen Davis, Werner Hacke, Markku Kaste, Patrick D. Lyden, for the mRECT Study Investigators, Monika Fierus, and for Bayer HealthCare AG
Stroke. 2009;40:3518-3525; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.551382
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Statin Treatment and Stroke Outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial
Larry B. Goldstein, Pierre Amarenco, Justin Zivin, Michael Messig, Irfan Altafullah, Alfred Callahan, Michael Hennerici, Mary J. MacLeod, Henrik Sillesen, Richard Zweifler, K. Michael, A. Welch on behalf of the SPARCL Investigators
Stroke. 2009;40:3526-3531; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.557330
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Neurological Outcomes in Patients With Ischemic Stroke Receiving Enoxaparin or Heparin for Venous Thromboembolism Prophylaxis: Subanalysis of the Prevention of VTE After Acute Ischemic Stroke With LMWH (PREVAIL) Study
Carlos S. Kase, Gregory W. Albers, Christopher Bladin, Cesare Fieschi, Alberto A. Gabbai, William O'Riordan, Graham F. Pineo on behalf of the PREVAIL Investigators
Stroke. 2009;40:3532-3540; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.555003
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Effect of Telmisartan on Functional Outcome, Recurrence, and Blood Pressure in Patients With Acute Mild Ischemic Stroke: A PRoFESS Subgroup Analysis
Philip M. W. Bath, Reneé H. Martin, Yuko Palesch, Daniel Cotton, Salim Yusuf, Ralph Sacco, Hans-Christoph Diener, Danilo Toni, Conrado Estol, Robin Roberts for the PRoFESS Study Group
Stroke. 2009;40:3541-3546; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.555623
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Point-of-Care International Normalized Ratio Testing Accelerates Thrombolysis in Patients With Acute Ischemic Stroke Using Oral Anticoagulants
Timolaos Rizos, Christian Herweh, Ekkehart Jenetzky, Christoph Lichy, Peter Arthur Ringleb, Werner Hacke, and Roland Veltkamp
Stroke. 2009;40:3547-3551; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.562769
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First Food and Drug Administration-Approved Prospective Trial of Primary Intracranial Stenting for Acute Stroke: SARIS (Stent-Assisted Recanalization in Acute Ischemic Stroke)
Elad I. Levy, Adnan H. Siddiqui, Annemarie Crumlish, Kenneth V. Snyder, Erik F. Hauck, David J. Fiorella, L. Nelson Hopkins, and J Mocco
Stroke. 2009;40:3552-3556; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.561274
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Differential Impact of Lacunes and Microvascular Lesions on Poststroke Depression
Micaela Santos, Gabriel Gold, Enikö Kövari, Francois R. Herrmann, Vasilis P. Bozikas, Constantin Bouras, and Panteleimon Giannakopoulos
Stroke. 2009;40:3557-3562; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.548545
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Severity of Hypoperfusion in Distinct Brain Regions Predicts Severity of Hemispatial Neglect in Different Reference Frames
Peyman Shirani, Julia Thorn, Cameron Davis, Jennifer Heidler-Gary, Melissa Newhart, Rebecca F. Gottesman, and Argye E. Hillis
Stroke. 2009;40:3563-3566; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.561969
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Three-Year Survival and Stroke Recurrence Rates in Patients With Primary Intracerebral Hemorrhage
Elisabet Zia, Gunnar Engström, Peter J. Svensson, Bo Norrving, and Hélène Pessah-Rasmussen
Stroke. 2009;40:3567-3573; published online before print September 3 2009, doi:10.1161/STROKEAHA.109.556324
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Stroke Patient Outcomes in US Hospitals Before the Start of the Joint Commission Primary Stroke Center Certification Program
Judith H. Lichtman, Norrina B. Allen, Yun Wang, Emi Watanabe, Sara B. Jones, and Larry B. Goldstein
Stroke. 2009;40:3574-3579; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.561472
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US Geographic Distribution of rt-PA Utilization by Hospital for Acute Ischemic Stroke
Dawn Kleindorfer, Yingying Xu, Charles J. Moomaw, Pooja Khatri, Opeolu Adeoye, and Richard Hornung
Stroke. 2009;40:3580-3584; published online before print October 1 2009, doi:10.1161/STROKEAHA.109.554626
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Survival, Hazard Function for a New Event, and Healthcare Utilization Among Stroke Patients
65 Years
Lena Olai, Marianne Omne-Pontén, Lars Borgquist, and Kurt Svärdsudd
Stroke. 2009;40:3585-3590; published online before print August 20 2009, doi:10.1161/STROKEAHA.109.556720
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Routine Use of Intravenous Low-Dose Recombinant Tissue Plasminogen Activator in Japanese Patients: General Outcomes and Prognostic Factors From the SAMURAI Register
Kazunori Toyoda, Masatoshi Koga, Masaki Naganuma, Yoshiaki Shiokawa, Jyoji Nakagawara, Eisuke Furui, Kazumi Kimura, Hiroshi Yamagami, Yasushi Okada, Yasuhiro Hasegawa, Kazuomi Kario, Satoshi Okuda, Kazutoshi Nishiyama, Kazuo Minematsu for the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) Study Investigators
Stroke. 2009;40:3591-3595; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.562991
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Attenuation of Brain Response to Vascular Endothelial Growth Factor-Mediated Angiogenesis and Neurogenesis in Aged Mice
Peng Gao, Fanxia Shen, Rodney Allanigue Gabriel, David Law, Ethan Yang, Guo-Yuan Yang, William L. Young, and Hua Su
Stroke. 2009;40:3596-3600; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.561050
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Anxiety After Cardiac Arrest/Cardiopulmonary Resuscitation: Exacerbated by Stress and Prevented by Minocycline
Gretchen N. Neigh, Kate Karelina, Erica R. Glasper, Stephanie L.K. Bowers, Ning Zhang, Phillip G. Popovich, and A. Courtney DeVries
Stroke. 2009;40:3601-3607; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.564146
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NCX1 Expression and Functional Activity Increase in Microglia Invading the Infarct Core
Francesca Boscia, Rosaria Gala, Anna Pannaccione, Agnese Secondo, Antonella Scorziello, Gianfranco Di Renzo, and Lucio Annunziato
Stroke. 2009;40:3608-3617; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.557439
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Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation
John R. Sims, Sae-Won Lee, Kamil Topalkara, Jianhua Qiu, Jian Xu, Zhipeng Zhou, and Michael A. Moskowitz
Stroke. 2009;40:3618-3626; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.561951
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Research Letters
Multi-Modal Reperfusion Therapy for Patients With Acute Anterior Circulation Stroke in Israel
Ronen R. Leker, Roni Eichel, David Arkadir, John M. Gomori, Guy Raphaeli, Tamir Ben-Hur, and Jose E. Cohen
Stroke. 2009;40:3627-3630; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.562058
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Pre–Tissue Plasminogen Activator Blood Pressure Levels and Risk of Symptomatic Intracerebral Hemorrhage
Georgios Tsivgoulis, James L. Frey, Murray Flaster, Vijay K. Sharma, Annabelle Y. Lao, Steven L. Hoover, Wei Liu, Elefterios Stamboulis, Anne W. Alexandrov, Marc D. Malkoff, and Andrei V. Alexandrov
Stroke. 2009;40:3631-3634; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.564096
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CME
Intravenous Tissue Plasminogen Activator in Patients With Cocaine-Associated Acute Ischemic Stroke
Sheryl Martin-Schild, Karen C. Albright, Vivek Misra, Maria Philip, Andrew D. Barreto, Hen Hallevi, James C. Grotta, and Sean I. Savitz
Stroke. 2009;40:3635-3637; published online before print September 10 2009, doi:10.1161/STROKEAHA.109.559823
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Cerebral Microbleeds in Ischemic Stroke Patients on Warfarin Treatment
Dilek Necioglu Orken, Gulay Kenangil, Ender Uysal, and Hulki Forta
Stroke. 2009;40:3638-3640; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.559450
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Comments, Opinions, and Reviews
Defeating Normal Thermoregulatory Defenses: Induction of Therapeutic Hypothermia
Daniel I. Sessler
Stroke. 2009;40:e614-e621; published online before print August 13 2009, doi:10.1161/STROKEAHA.108.520858
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Topical Review
Pharmacogenetics and Stroke
James F. Meschia
Stroke. 2009;40:3641-3645; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.562231
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Cochrane Corner
Interventions in the Management of Serum Lipids for Preventing Stroke Recurrence
Bradley N. Manktelow and John F. Potter
Stroke. 2009;40:e622-e623; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.561860
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Surgery for Primary Supratentorial Intracerebral Hematoma: A Meta-Analysis of 10 Randomized Controlled Trials
Kameshwar Prasad, A. David Mendelow, and Barbara Gregson
Stroke. 2009;40:e624-e626; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.561928
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Overground Physical Therapy Gait Training for Chronic Stroke Patients With Mobility Deficits
Rebecca A. States, Evangelos Pappas, and Yasser Salem
Stroke. 2009;40:e627-e628; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.558940
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AHA Scientific Statement
Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association
Richard E. Latchaw, Mark J. Alberts, Michael H. Lev, John J. Connors, Robert E. Harbaugh, Randall T. Higashida, Robert Hobson, Chelsea S. Kidwell, Walter J. Koroshetz, Vincent Mathews, Pablo Villablanca, Steven Warach, Beverly Walters on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, and the Interdisciplinary Council on Peripheral Vascular Disease
Stroke. 2009;40:3646-3678; published online before print September 24 2009, doi:10.1161/STROKEAHA.108.192616
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Letters to the Editor
Local Symptoms and Recanalization in Spontaneous Carotid Artery Dissection
Antti J. Metso, Tiina M. Metso, and Turgut Tatlisumak
Stroke. 2009;40:e629; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.552463
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Response to Letter by Metso et al
Krassen Nedeltchev, Stefan Bickel, Marcel Arnold, Hakan Sarikaya, Dimitrios Georgiadis, Matthias Sturzenegger, Heinrich P. Mattle, and Ralf W. Baumgartner
Stroke. 2009;40:e630-e631; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.552505
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Expanding Recombinant Tissue Plasminogen Activator Time Window Is Premature
Brian S. Alper and Cynthia B. Brown
Stroke. 2009;40:e632; published online before print October 1 2009, doi:10.1161/STROKEAHA.109.560615
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Guidelines For Extending the Tissue Plasminogen Activator Treatment Window for Ischemic Stroke
Andrew W. Asimos
Stroke. 2009;40:e633; published online before print October 1 2009, doi:10.1161/STROKEAHA.109.559633
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Response to Letters by Asimos and by Alper and Brown
Gregory J. del Zoppo, Jeffrey L. Saver, Edward C. Jauch, Harold P. Adams On behalf of the American Heart Association Stroke Council, American Heart Assocation
Stroke. 2009;40:e634-e635; published online before print October 1 2009, doi:10.1161/STROKEAHA.109.560086
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Normobaric Hyperoxia Treatment in Acute Ischemic Stroke
Dimiter Ivanov Hadjiev and Petya Pencheva Mineva
Stroke. 2009;40:e636; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563155
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Response to Letter by Hadjiev and Mineva
Wenlan Liu and Ke Jian Liu
Stroke. 2009;40:e637; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563635
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Value of Central Event Adjudication
David R. Kerr and Elaine Nasco
Stroke. 2009;40:e638; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.562181
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Response to Letter by Kerr and Nasco
Bruce Neal, Toshiharu Ninomiya, Geoff Donnan, Neil Anderson, Chris Bladin, Brian Chambers, Gary Gordon, Norman Sharpe, John Chalmers, and Mark Woodward
Stroke. 2009;40:e639-e640; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563676
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How to Improve the Quality of a Clinical Trial on Traditional Chinese Medicine for Stroke
Bo Wu and Ming Liu
Stroke. 2009;40:e641-e642; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563072
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Response to Letter by Wu and Liu
Junhua Zhang, Francesca Menniti-Ippolito, Xiumei Gao, Fabio Firenzuoli, Boli Zhang, Marco Massari, Hongcai Shang, Yuhong Huang, Rita Ferrelli, Limin Hu, Alice Fauci, Ranieri Guerra, and Roberto Raschetti
Stroke. 2009;40:e643-e644; published online before print September 17 2009, doi:10.1161/STROKEAHA.109.563643
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Platelet Dysfunction in Intraparenchymal Hemorrhage
Claire J. Creutzfeldt, Kyra J. Becker, W.T. Longstreth, Jr, David L. Tirschwell, and Jonathan R. Weinstein
Stroke. 2009;40:e645; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.561191
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Response to Letter by Creutzfeldt et al
Andrew M. Naidech, Richard A. Bernstein, Bernard R. Bendok, Mark J. Alberts, and H. Hunt Batjer
Stroke. 2009;40:e646; published online before print September 24 2009, doi:10.1161/STROKEAHA.109.561647
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