TABLE 11. Characteristics of Patients With Ischemic Stroke Who Could Be Treated With rtPA

INR indicates international normalized ratio; aPTT, activated partial thromboplastin time.
Diagnosis of ischemic stroke causing measurable neurological deficit
The neurological signs should not be clearing spontaneously.
The neurological signs should not be minor and isolated.
Caution should be exercised in treating a patient with major deficits.
The symptoms of stroke should not be suggestive of subarachnoid hemorrhage.
Onset of symptoms <3 hours before beginning treatment
No head trauma or prior stroke in previous 3 months
No myocardial infarction in the previous 3 months
No gastrointestinal or urinary tract hemorrhage in previous 21 days
No major surgery in the previous 14 days
No arterial puncture at a noncompressible site in the previous 7 days
No history of previous intracranial hemorrhage
Blood pressure not elevated (systolic <185 mm Hg and diastolic <110 mm Hg)
No evidence of active bleeding or acute trauma (fracture) on examination
Not taking an oral anticoagulant or, if anticoagulant being taken, INR ≤1.7
If receiving heparin in previous 48 hours, aPTT must be in normal range.
Platelet count ≥100 000 mm3
Blood glucose concentration ≥50 mg/dL (2.7 mmol/L)
No seizure with postictal residual neurological impairments
CT does not show a multilobar infarction (hypodensity >1/3 cerebral hemisphere).
The patient or family members understand the potential risks and benefits from treatment.