Table 3.

Association Between Baseline Parameters and Risk of Ischemic Stroke by Univariable Analyses*

ParameterHazard Ratio (95% CI)P Value
Age4.16 (2.13–8.137)<0.0001
Sex (M/F)2.07 (0.74–5.74)0.164
Previous niacin0.56 (0.24–1.32)0.186
On statin at baseline0.75 (0.27–2.08)0.578
Aspirin at baseline0.51 (0.24–1.09)0.085
Antiplatelet agents at baseline0.75 (0.27–2.09)0.582
ACE inhibitor/ARB0.94 (0.50–1.77)0.852
Any BP-lowering drugs0.69 (0.21–2.20)0.526
History of diabetes mellitus0.92 (0.51–1.65)0.768
History of PVD1.02 (0.46, 2.27)0.964
Previous MI1.17 (0.67–2.062)0.576
Previous stroke/TIA2.07 (1.17–3.67)0.013
Hypertension0.86 (0.47–1.58)0.632
Atrial fibrillation1.66 (0.74–3.70)0.217
Metabolic syndrome0.88 (0.44–1.76)0.938
LDL cholesterol
 Highest vs lowest tertile0.76 (0.38–1.52)0.740
 Middle vs lowest tertile0.87 (0.45–1.68)
 Highest vs lowest tertile0.99 (0.50–1.97)0.992
 Middle vs lowest tertile0.96 (0.49–1.88)
HDL cholesterol
 Lowest vs highest tertile1.52 (0.78–2.98)0.349
 Middle vs highest tertile1.01 (0.48–2.13)
Total/HDL cholesterol ratio
 Highest vs lowest tertile0.86 (0.43–1.71)0.909
 Middle vs lowest tertile0.94 (0.48–1.82)
 Highest vs lowest tertile1.30 (0.67–2.50)0.307
 Middle vs lowest tertile0.74 (0.35–1.55)
 Highest vs lowest tertile0.56 (0.28–1.16)0.294
 Middle vs lowest tertile0.81 (0.42–1.56)
ApoB/ApoA ratio
 Highest vs lowest tertile1.31 (0.61–2.84)0.234
 Middle vs lowest tertile1.82 (0.90–3.68)
 Highest vs lowest tertile2.27 (0.99–5.22)0.044
 Middle vs lowest tertile2.78 (1.24–6.21)
  • ACE indicates angiotensin-converting enzyme; ApoA, apolipoprotein A; ApoB, apolipoprotein B; ARB, angiotensin receptor blocker; BP, blood pressure; CI, confidence interval; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MI, myocardial infarction; PVD, peripheral vascular disease; and TIA, transient ischemic attack.

  • * Adjusted for age >65 y (yes/no).