Table 1.

Summary of Reported Studies in Patients With Simultaneous Intracerebral Hemorrhages (SMICHs)

Author, YearSMICH/Single ICH (n/total, %)CountrySMICH PathogenesisAgeTotal ICH Volume, mLSMICH Mortality
Weisberg,8 198112/600 (2%)United StatesUndetermined: 12 (100%)NRNR3/12 (33%), follow-up time not defined
Mauriño et al,9 20014/142 (2.8%)ArgentinaHypertension: 4 (100%)55NR0/4 (0%) at 3 mo
Yen et al,4 200510/1304 (0.8%)TaiwanHypertension: 10 (100%)61NR6/10 (60%) at 6 mo
Sorimachi et al,7 20079/190 (4.7%)JapanHypertension: 9 (100%)6911NR
Stemer et al,6 201029/522 (5.6%)United StatesCAA: 3 (10.3%); hypertension: 11 (37.9%); secondary ICH:* 15 (51.7%)5977/29 (24%)
Takeuchi et al,5 201120/2198 (0.9%)JapanHypertension (100%)61289/20 (45%) at discharge
Laiwattana et al,11 2014105/NRMixedNR61NR46/105 (44%), follow-up time not defined
Yeh et al,12 2014136/3785 (3.6%)TaiwanCAA: 14 (10.3%); hypertension: 14 (10.3%); structural vascular: 3 (2.2%); medication: 16 (11.8%); systemic: 70 (51.5%); undefined: 19 (13.9%)NRNRNR
Chen et al,10 201632/562 (5.7%)FranceCAA: 8 (25.0%); deep vessel vasculopathy: 5 (15.6%); undefined: 19 (59.4%)693125/32 (78%) at 6 mo
Current study85/1452 (5.9%)Australia, FinlandCAA: 27 (31.7%); hypertension: 17 (20.0%); structural vascular: 5 (5.9%); medication: 14 (16.5%); systemic: 10 (11.8%); undefined: 12 (14.1%)742231/83 (37%) at 3 mo
  • CAA indicates cerebral amyloid angiopathy; ICH, intracerebral hemorrhage; and NR, not reported.

  • * Stemer et al classified ICH as secondary in patients with coagulopathy, treatment with anticoagulant, history of illicit drug abuse, with cerebral vasculitis, or infective endocarditis at the time of ICH.

  • This systematic review consists of publications in both English and non-English journals and contains both case reports and case series including 34 patients from series by Mauriño et al,9 Yen et al,4 and Takeuchi et al.5