Table 3.

Baseline Clinical and Radiological Factors and Mortality in Patients With and Without SMICHs

All (n=1452)SMICH (n=85)Single ICH (n=1367)P Value
Age, y70 (60–79)74 (61–81)70 (60–79)0.258
Male sex831 (57%)36 (42%)795 (58%)0.004
GCS14 (10–15)12 (8–15)14 (10–15)0.008
Warfarin203 (14%)9 (11%)194 (14%)0.422*
Antiplatelet432 (30%)29 (34%)403 (30%)0.364
Statin312 (22%)20 (24%)292 (21%)0.637
Atrial fibrillation223 (15%)17 (20%)206 (15%)0.221
Hypertension951 (66%)55 (65%)901 (66%)0.820
Dyslipidemia321 (22%)17 (20%)304 (22%)0.629
Diabetes mellitus243 (17%)12 (14%)231 (17%)0.505
Ischemic heart disease136 (9%)8 (9%)128 (9%)1.000*
Previous ischemic stroke128 (9%)9 (11%)119 (9%)0.553
Previous ICH67 (5%)7 (8%)60 (4%)0.107
90-day mortality§494 (35%)31 (37%)463 (34%)0.610
Baseline ICH volume, mL15 (6–43)22 (6–58)15 (6–42)0.225
Ventricular extension608 (42%)30 (35%)578 (42%)0.205
Location<0.001
 Lobar512 (35%)50 (59%)462 (34%)<0.001
 Deep752 (52%)29 (34%)723 (52%)0.001
 Infratentorial199 (14%)6 (7%)193 (14%)0.073*
SMASH-U classification<0.001
 Amyloid344 (24%)27 (32%)317 (23%)0.071
 Hypertension528 (36%)17 (20%)511 (37%)0.001
 Medication198 (14%)14 (16%)184 (14%)0.433
 Structural64 (4%)5 (6%)59 (4%)0.418*
 Systemic defined55 (4%)10 (12%)45 (3%)<0.001
 Undefined263 (18%)12 (14%)251 (18%)0.324
  • Data are median (interquartile range) or n (%). GCS indicates Glasgow Coma Scale; ICH, intracerebral hemorrhage; SMASH-U, structural lesion, medication, amyloid angiopathy, systemic/other disease, hypertension, undetermined classification; and SMICH, simultaneous intracerebral hemorrhages.

  • * Fisher exact test.

  • Thirteen patients had missing baseline statin use data.

  • Sixteen patients had missing preexisting dyslipidemia data.

  • § Thirty-one patients had missing 90-day mortality data.

  • ICH volume in SMICH is sum of all the hematomas.